- Increased Risk with Pfizer-BioNTech Vaccination:
- Children vaccinated with Pfizer-BioNTech without prior SARS-CoV-2 infection were 159% more likely to get infected and 257% more likely to develop symptomatic COVID-19 compared to unvaccinated children without prior infection:
- Hazard Ratio (HR) for infection: 2.59 (95% CI: 1.27–5.28).
- HR for symptomatic COVID-19: 3.57 (95% CI: 1.10–11.63).
- Children vaccinated with Pfizer-BioNTech without prior SARS-CoV-2 infection were 159% more likely to get infected and 257% more likely to develop symptomatic COVID-19 compared to unvaccinated children without prior infection:
- Prior Infection Offers Robust Protection:
- Children with prior SARS-CoV-2 infection (unvaccinated) had a significantly lower risk of reinfection compared to unvaccinated, infection-naïve children:
- HR for infection: 0.28 (95% CI: 0.16–0.49).
- HR for symptomatic COVID-19: 0.21 (95% CI: 0.08–0.54).
- Children with prior SARS-CoV-2 infection (unvaccinated) had a significantly lower risk of reinfection compared to unvaccinated, infection-naïve children:
- No Protective Effect from Vaccination Alone:
- There was no significant reduction in the risk of infection or symptomatic COVID-19 for vaccinated children (Moderna or Pfizer-BioNTech) compared to unvaccinated children:
- HR for infection with vaccination alone: 1.23 (95% CI: 0.69–2.16).
- HR for symptomatic COVID-19 with vaccination alone: 1.61 (95% CI: 0.65–4.03).
- There was no significant reduction in the risk of infection or symptomatic COVID-19 for vaccinated children (Moderna or Pfizer-BioNTech) compared to unvaccinated children:
- Boosters Show No Significant Protection:
- Among children who received at least one bivalent booster dose, there was no significant reduction in infection or symptomatic COVID-19:
- HR for infection with a bivalent booster: 0.74 (95% CI: 0.37–1.48).
- HR for symptomatic COVID-19 with a bivalent booster: 1.04 (95% CI: 0.37–2.96).
- Among children who received at least one bivalent booster dose, there was no significant reduction in infection or symptomatic COVID-19:
- Pfizer mRNA 'Vaccinated' Children Significantly More Likely to Get COVID-19 Than Unvaccinated Peers
[link] [comments]